Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO
Garrett L. Lindsey, Thomas K. Hockley, Alejandro Villa Gomez, Andrew C. Marshall, William R. Brothers, Colin T. Finney, Jacob Gross, Archa H. Fox, Gene Wei-Ming Yeo, Bruno N. Melillo, Charles S. Bond, Benjamin F. Cravatt
This paper reports covalent ligands targeting the RNA-binding protein NONO, showing they stabilize mRNA interactions, remodel transcriptomes, and suppress cancer cell growth with high specificity.
Cell chemical biology · Jan 13, 2026Peer-reviewedBiochemistry