Andrew C. Marshall

Structural and functional characterisation of a reconstructed ancestral strigolactone receptor

This paper reconstructs an ancestral D14 strigolactone receptor and shows it has conserved substrate specificity but improved stability and activity compared to Arabidopsis D14.

Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO

This paper reports covalent ligands targeting the RNA-binding protein NONO, showing they stabilize mRNA interactions, remodel transcriptomes, and suppress cancer cell growth with high specificity.

Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates

This study identifies distinct roles of low-complexity regions in SFPQ for biomolecular condensate formation, showing the C-terminal region drives condensation while the N-terminal region inhibits it.