Jacob Gross

This study identifies a small molecule targeting PSME4, which stabilizes STAT1 and reprograms tumor inflammation, suppressing tumor growth by altering cytokine signaling.

This paper reports covalent ligands targeting the RNA-binding protein NONO, showing they stabilize mRNA interactions, remodel transcriptomes, and suppress cancer cell growth with high specificity.

The paper develops covalent ligands that specifically target a complexoform of TRMT112, revealing partner-specific functional effects through allosteric activation of METTL5.

The paper investigates replication origin over-activation in cancer cells and finds two distinct pools of origins are activated under different conditions.

BAMscale processes DNA sequencing datasets to generate normalized peak scores and scaled coverage tracks for visualization.