A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology
Yingying Zhang, Alden King-Yung Leung, Jin Joo Kang, Yu Sun, Guanxi Wu, Le Li, Jiayang Sun, Lily Cheng, Tian Qiu, Junke Zhang, Shayne D. Wierbowski, Shagun Gupta, James G. Booth, Haiyuan Yu
This paper introduces NetFlow3D, a framework that integrates protein structure and interaction networks to identify significant mutation clusters and modules in cancer, revealing biological processes not found by traditional methods.
Nature Communications · Jan 24, 2025Peer-reviewedSystems Biology