Tian Qiu

Activating p53Y220C with a Mutant-Specific Small Molecule

This paper develops a small molecule, TRAP-1, that activates mutant p53 by forming a ternary complex with BRD4, leading to p53 target gene upregulation and inhibition of cancer cell growth.

Design and Development of DNA Damage Chemical Inducers of Proximity (DD-CIP) for Targeted Cancer Therapy

This paper introduces DD-CIPs, bivalent molecules that induce DNA damage response and apoptosis in cancer cells, showing efficacy against PARPi-resistant cancers.

Development of Degraders and 2-pyridinecarboxyaldehyde (2-PCA) as a recruitment Ligand for FBXO22

This paper develops chemical probes for FBXO22, including a degrader and a recruitment ligand, to enable targeted protein degradation applications.

Activity-dependent post-translational regulation of palmitoylating and de-palmitoylating enzymes in the hippocampus

This study shows that synaptic activity affects post-translational modifications of palmitoylating enzymes but not depalmitoylating enzymes in the hippocampus.