A novel antidepressant acting via allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons
Jilin Zhang, Jinjin Duan, Luyu Ye, Wei Li, Haitao Zhou, Fang Liu, Tian Xiaoting, Yang Xie, Yiming Huang, Yidi Sun, Hu Zhou, Chenggang Huang, Yang Li, Shujia Zhu, Fei Guo
The paper identifies YY-23, a compound that inhibits GluN2D-containing NMDARs in GABAergic interneurons, showing antidepressant effects in animal models.
bioRxiv · Nov 6, 2022 · PreprintNeuroscience