Epigenetic control of Topoisomerase 1 activity presents a cancer vulnerability
Tae-Hee Lee, Colina X. Qiao, Vladislav Kuzin, Yubo Shi, Marina Farkaš, Zhiyan Zhao, Vijayalalitha Ramanarayanan, Tongyu Wu, Tianyi Guan, Xianzhen Zhou, David Corujo, Marcus Buschbeck, Laura Baranello, Philipp Oberdoerffer
The paper identifies macroH2A1 splicing as a regulator of TOP1 activity and shows its impact on cancer vulnerability to TOP1 inhibitors.
Nature Communications · Aug 12, 2025Peer-reviewedMolecular Biology