Author

Marcus Buschbeck

Josep Carreras Leukaemia Research InstituteORCID 0000-0002-3218-4567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alejandro VaqueroiD· 1 shared Alessandro IanniiD· 1 shared Berta N. VázqueziD· 1 shared Carla Vendrell-AyatsiD· 1 shared Carolina de la TorreiD· 1 shared Colina X. Qiao· 1 shared Cristina BugésiD· 1 shared Cristina Moreta-MoraledaiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMolecular Biology

Alejandro VaqueroORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Loss-of-Function genetic Screen Unveils Synergistic Efficacy of PARG Inhibition with Combined 5-Fluorouracil and Irinotecan Treatment in Colorectal Cancer

Cristina Queralt, Cristina Moreta-Moraleda, Marta Costa, Ferran Grau‐Leal, Jeannine Diesch, Carla Vendrell-Ayats, Eva Musulén, Roni H G Wright, Cristina Bugés, José Luis Manzano, Sara Cabrero‐de las Heras, Johannes A. Zuber, Marcus Buschbeck, Sonia Vanina Forcales, Eva Martinez‐Balibrea

This study identifies PARG as a therapeutic target in colorectal cancer, showing that its inhibition synergizes with 5FU and irinotecan to improve treatment efficacy.

Clinical and Translational Medicine · Dec 1, 2025Peer-reviewedCancer Biology

Epigenetic control of Topoisomerase 1 activity presents a cancer vulnerability

Tae-Hee Lee, Colina X. Qiao, Vladislav Kuzin, Yubo Shi, Marina Farkaš, Zhiyan Zhao, Vijayalalitha Ramanarayanan, Tongyu Wu, Tianyi Guan, Xianzhen Zhou, David Corujo, Marcus Buschbeck, Laura Baranello, Philipp Oberdoerffer

The paper identifies macroH2A1 splicing as a regulator of TOP1 activity and shows its impact on cancer vulnerability to TOP1 inhibitors.

Nature Communications · Aug 12, 2025Peer-reviewedMolecular Biology

SirT7 auto-ADP-ribosylation regulates glucose starvation response through macroH2A1.1

Nicolás G. Simonet, Joshua K. Thackray, Berta N. Vázquez, Alessandro Ianni, Maria Espinosa‐Alcantud, Julia Morales‐Sanfrutos, Sarah Hurtado-Bagès, Eduard Sabidó, Marcus Buschbeck, Jay A. Tischfield, Carolina de la Torre, Manel Esteller, Thomas W Braun, Mireia Olivella, Lourdes Serrano, Alejandro Vaquero

This study identifies SirT7's dual role as a deacetylase and mADPRT enzyme, showing its regulation of glucose starvation response via interaction with macroH2A1.1.

bioRxiv · Aug 5, 2019 · PreprintMolecular Biology