Dengue virus structural proteins are expressed on the surface of DENV-infected cells and are a target for antibody-dependent cellular phagocytosis
Mitchell J. Waldran, Elizabeth A Kurtz, C. J. Gebo, Timothy J Rooney, Frank A. Middleton, Nathan H. Roy, Jeffrey R. Currier, Adam Tully Waickman
This study shows DENV structural proteins are surface-expressed on infected cells and can be targeted by antibodies for phagocytic clearance, bypassing ADE risks.
Open Forum Infectious Diseases · Dec 10, 2024Peer-reviewedImmunology