Chad Gebo

This study identifies BCR-dependent enhancement (BDE) as a mechanism by which DENV infects B cells, showing that BCR-E protein interactions and dynamin-mediated entry are critical for viral replication in these cells.

This study shows DENV structural proteins are surface-expressed on infected cells and can be targeted by antibodies for phagocytic clearance, bypassing ADE risks.

This study shows that DENV infection enhances B cells via their BCR, linking ADE potential to B cell susceptibility and highlighting B cells as a key reservoir in immune-mediated DENV enhancement.