Targeting a malaria merozoite surface protein with mRNA vaccine generates multifunctional antibodies
Adam Thomas, Tom Runz, Timothy K.C. Ho, Stewart A. Fabb, Chee Leng Lee, Sandra Chishimba, Rekha Shandre Mugan, Linda Reiling, Liriye Kurtovic, Claretta S. D'souza, Colin William Pouton, James G. Beeson
This study evaluates mRNA vaccines encoding PfMSP2, showing they induce strong IgG responses and functional antibodies against malaria merozoites, comparable to or better than a protein-based vaccine.
Frontiers in Immunology · Sep 16, 2026Peer-reviewedImmunology