James G. Beeson

Nanobodies against Plasmodium vivax AMA1 block parasite invasion

The paper identifies nanobodies against PvAMA1 that inhibit Plasmodium vivax and falciparum invasion by binding novel epitopes distinct from known antibodies.

Targeting a malaria merozoite surface protein with mRNA vaccine generates multifunctional antibodies

This study evaluates mRNA vaccines encoding PfMSP2, showing they induce strong IgG responses and functional antibodies against malaria merozoites, comparable to or better than a protein-based vaccine.

Functional analysis of novel microneme proteins from Plasmodium vivax blood stages identifies vaccine candidates

The paper identifies and characterizes two novel Plasmodium vivax merozoite proteins, PvMP45 and PvMP36, which bind reticulocyte receptors and are targets of protective antibodies, suggesting their potential as vaccine candidates.

An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies

This study shows that PfMSP2 modulates the susceptibility of merozoites to inhibitory antibodies targeting other invasion proteins, altering malaria vaccine strategies.

Dose-sparing self-amplifying RNA vaccine induces high functional antibodies to blood-stage Plasmodium falciparum malaria

This study develops a self-amplifying RNA vaccine against Plasmodium falciparum malaria that induces high functional antibodies with Fc-mediated activities using a dose-sparing regimen.

Functionally Distinct pTfh1 Subsets with Roles in Malaria-Specific Immunity

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.

Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection

This study shows that latent cytomegalovirus infection reduces antibody responses to malaria infection and vaccination by altering Tfh cell subsets and their activation.

IgM plays a prominent role in naturally acquired immunity against Plasmodium falciparum gametocytes

This study identifies IgM as a key antibody isotype in immune responses against Plasmodium falciparum gametocytes, showing its superior complement fixation activity compared to IgG.

Display of malaria transmission-blocking antigens on chimeric duck hepatitis B virus-derived virus-like particles produced in Hansenula polymorpha

This study develops a platform to display malaria transmission-blocking antigens on virus-like particles using yeast expression systems and demonstrates efficient production and purification of chimeric VLPs containing Pfs25 and Pfs230 variants.