Colin William Pouton

This study evaluates mRNA vaccines encoding PfMSP2, showing they induce strong IgG responses and functional antibodies against malaria merozoites, comparable to or better than a protein-based vaccine.

This paper introduces a long-read sequencing method to directly quantify synthetic mRNA abundance, integrity, and host response in vivo.

This study identifies synaptic vesicle endocytosis in nociceptors as a driver of chronic pain and shows that targeting it with CRISPR/dCas9-R via lipid nanoparticles provides long-lasting pain relief without affecting acute pain responses.

This paper develops stable, clamp-free Sarbecovirus spike trimers for vaccine development, showing they elicit high neutralizing antibodies and broad protection in mice.

This paper introduces an antibody capture system for LNPs that enhances mRNA delivery and gene expression by enabling precise targeting to T cells with minimal off-target effects.

The paper determines the cryo-EM structure of the Plasmodium falciparum Pfs230-Pfs48/45 fertilization complex and identifies domains critical for function and vaccine design.

This study develops an LNP-mRNA vaccine against Mycobacterium tuberculosis that induces strong immune responses and protects mice from infection, with potential for human application.

This paper shows that temporarily blocking type I interferon during viral infection boosts CD8+ T cell memory and vaccine effectiveness by promoting TSCM cell formation.

This study shows that early viral delivery of GDNF improves survival and function of human stem cell grafts in Parkinson's disease models.

This study identifies that amyloid plaque phagocytosis through Hif1α controls microglial phenotypes in Alzheimer’s disease in both mice and humans.