Timothy K.C. Ho

Targeting a malaria merozoite surface protein with mRNA vaccine generates multifunctional antibodies

This study evaluates mRNA vaccines encoding PfMSP2, showing they induce strong IgG responses and functional antibodies against malaria merozoites, comparable to or better than a protein-based vaccine.

Dose-sparing self-amplifying RNA vaccine induces high functional antibodies to blood-stage Plasmodium falciparum malaria

This study develops a self-amplifying RNA vaccine against Plasmodium falciparum malaria that induces high functional antibodies with Fc-mediated activities using a dose-sparing regimen.