Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells.
Linda V. Sinclair, Tom Youdale, Laura Spinelli, Milica Gakovic, Alistair J. Langlands, Shalini Pathak, Andrew J.M. Howden, Ian G. Ganley, Doreen Ann Cantrell
This study shows antigen and cytokines repress autophagy in CD8 T cells, shaping mitochondrial function, migration, and effector machinery through differential proteome pruning.
Nature Immunology · Feb 27, 2025Peer-reviewedImmunology