Alistair J. Langlands

A high throughput system reveals distinct segmentation clock phase responses in hiPSC-derived organoids

The paper develops a high-throughput system to study segmentation clock phase responses in hiPSC-derived somitoids using image-based screening and mathematical modeling.

Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD

This study identifies NSUN1-mediated m5C RNA methylation as a driver of TDP-43 cytoplasmic accumulation and neurotoxicity in ALS/FTD.

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells.

This study shows antigen and cytokines repress autophagy in CD8 T cells, shaping mitochondrial function, migration, and effector machinery through differential proteome pruning.

SILAC-based quantitative proteomic analysis of Drosophila gastrula stage embryos mutant for fibroblast growth factor signaling

This study uses SILAC-based proteomics to analyze global proteome changes in Drosophila embryos lacking the FGF receptor Htl during gastrulation, identifying down- and up-regulated protein classes.