Linda V. Sinclair

This study shows that chronic extracellular acidosis remodels lysosomes in CD8+ T cells, impairing their cytotoxicity by depleting granzyme B through vesicle release.

The paper quantifies physiological fatty acid uptake in vivo and shows that nutrient accessibility differs from uptake capacity, shaped by tissue architecture and systemic constraints.

This study identifies translational repression and mitochondrial loss in NK cells as key factors limiting their persistence in suppressive tumour microenvironments.

This study shows CD4+ T cells rely more on asparagine uptake than CD8+ T cells for activation, differentiation, metabolism, and autophagy, with CD8+ cells expressing more ASNS.

This study shows that autophagy regulates asymmetric inheritance of old mitochondria in CD8+ T cells, which influences their metabolic state and memory potential.

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

This paper shows that inhibiting ABHD11 reduces T cell cytokine production and alleviates autoimmunity by altering sterol metabolism and LXR activation.

This study shows antigen and cytokines repress autophagy in CD8 T cells, shaping mitochondrial function, migration, and effector machinery through differential proteome pruning.

This study maps the proteomic changes in B cells during activation and shows how mTORC1, MYC, and iron regulate protein production and growth.

This study shows that LPS induces metabolic changes in B cells, including amino acid uptake and cholesterol metabolism, which are essential for proliferation.

This study compares the proteomes of human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs), finding quantitative differences in protein expression affecting growth, metabolism, and secreted factors.

The paper compares proteomic profiles of human and mouse microglia from different sources, revealing significant differences between in vitro and ex vivo cultures.

This study shows that iron deficiency in people with obesity impairs NK cell mitochondrial function and cytokine production.