Laura Spinelli

This study shows that PTEN's protein phosphatase activity is essential for embryonic development and tumor suppression in mice, as demonstrated by mutant mice with impaired protein phosphatase activity.

The paper uses mass spectrometry to analyze proteomic and metabolic changes in CD4⁺ and CD8⁺ T cells during colitis-associated colorectal cancer in mice, revealing distinct adaptations between the two cell types.

This study shows PIM kinases selectively regulate IL-2-driven protein synthesis and trafficking in CD8 T cells, without major effects on transcriptional programs.

This study shows antigen and cytokines repress autophagy in CD8 T cells, shaping mitochondrial function, migration, and effector machinery through differential proteome pruning.