Dihydroxy-Metabolites of Dihomo-gamma-linolenic Acid Drive Ferroptosis- Mediated Neurodegeneration
Morteza Sarparast, Elham Pourmand, Jennifer Hinman, Derek Vonarx, Tommy Reason, Fan Zhang, Shreya Paithankar, Bin Chen, Babak Borhan, Jennifer L. Watts, Jamie K. Alan, Kin Sing Stephen Lee
The paper identifies dihydroxyeicosadienoic acid as a metabolite of DGLA that induces ferroptosis-mediated neurodegeneration in dopaminergic neurons.
ACS Central Science · Mar 16, 2023Peer-reviewedNeuroscience