Author

Morteza Sarparast

Michigan State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Jamie K. AlaniD· 3 shared Kin Sing Stephen LeeiD· 3 shared Derek Vonarx· 2 shared Elham Pourmand· 2 shared Jennifer HinmaniD· 2 shared Babak BorhaniD· 1 shared Bin CheniD· 1 shared Brian Johnson· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Jamie K. AlanORCID

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3 papers

Recent·Most cited

A Robust Chemical-free Platform for Age-Synchronized Caenorhabditis elegans Populations Maintenance for High-Throughput Screening in Aging Studies

Fatemeh Yousefsaber, Morteza Sarparast, Brian Johnson, Jamie K. Alan, Kin Sing Stephen Lee

This paper introduces a chemical-free method to maintain age-synchronized C. elegans populations in a 96-well plate for 12 days, enabling high-throughput screening of compounds and RNAi libraries.

bioRxiv · Jan 30, 2026 · PreprintPharmacology & Toxicology

Cytochrome P450 and Epoxide Hydrolase Metabolites in Aβ and tau-induced Neurodegeneration: Insights from Caenorhabditis elegans

Morteza Sarparast, Jennifer Hinman, Elham Pourmand, Derek Vonarx, Leslie Ramirez, Wenjuan Ma, Nicole F. Liachko, Jamie K. Alan, Kin Sing Stephen Lee

This study identifies CYP and EH metabolites involved in Aβ and tau-induced neurodegeneration in C. elegans, showing that EH inhibition reduces neurodegeneration by altering the epoxy-to-hydroxy ratio of CYP-EH metabolites.

bioRxiv · Oct 2, 2023 · PreprintNeuroscience

Dihydroxy-Metabolites of Dihomo-gamma-linolenic Acid Drive Ferroptosis- Mediated Neurodegeneration

Morteza Sarparast, Elham Pourmand, Jennifer Hinman, Derek Vonarx, Tommy Reason, Fan Zhang, Shreya Paithankar, Bin Chen, Babak Borhan, Jennifer L. Watts, Jamie K. Alan, Kin Sing Stephen Lee

The paper identifies dihydroxyeicosadienoic acid as a metabolite of DGLA that induces ferroptosis-mediated neurodegeneration in dopaminergic neurons.

ACS Central Science · Mar 16, 2023Peer-reviewedNeuroscience