Jennifer L. Watts

This study shows that a defined microbial community remodels host metabolism and pathogen resistance in C. elegans by altering transcriptional pathways and physiological traits.

This study investigates the roles of Piga and Pgap2 in brain development using genetic ablation models, finding that Piga is critical for survival in the cerebellum while Pgap2 ablations are less severe.

This study identifies NHR-49 as a regulator of stress resilience and proteostasis in C. elegans, linking lipid homeostasis to proteotoxic stress responses.

The paper identifies dihydroxyeicosadienoic acid as a metabolite of DGLA that induces ferroptosis-mediated neurodegeneration in dopaminergic neurons.

The paper identifies ferroptosis regulators using a compendium of kinetic cell death modulatory profiles from 1,833 small molecules.

The paper evaluates tissue-specific RNAi strains in C. elegans and identifies a suitable genetic background for constructing robust tissue-specific RNAi strains.

The paper shows that TEAD4/YAP1/WWTR1 repress Sox2 expression before the 16-cell stage in mouse embryos, preventing premature pluripotency.