Kin Sing Stephen Lee

This paper introduces a chemical-free method to maintain age-synchronized C. elegans populations in a 96-well plate for 12 days, enabling high-throughput screening of compounds and RNAi libraries.

This study identifies CYP and EH metabolites involved in Aβ and tau-induced neurodegeneration in C. elegans, showing that EH inhibition reduces neurodegeneration by altering the epoxy-to-hydroxy ratio of CYP-EH metabolites.

The paper identifies dihydroxyeicosadienoic acid as a metabolite of DGLA that induces ferroptosis-mediated neurodegeneration in dopaminergic neurons.