NeurosciencebioRxivPreprint
Cytochrome P450 and Epoxide Hydrolase Metabolites in Aβ and tau-induced Neurodegeneration: Insights from Caenorhabditis elegans
Morteza Sarparast, Jennifer Hinman, Elham Pourmand…·Kin Sing Stephen Lee
This study identifies CYP and EH metabolites involved in Aβ and tau-induced neurodegeneration in C. elegans, showing that EH inhibition reduces neurodegeneration by altering the epoxy-to-hydroxy ratio of CYP-EH metabolites.
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