Author

Tomohiro Sugihara

Osaka Metropolitan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:non-human primate· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

Akihisa TerakitaiD· 3 shared Mitsumasa KOYANAGIiD· 3 shared Makoto IwasakiiD· 2 shared Yukiya Kakeyama· 2 shared Yusuke SakaiiD· 2 shared Aysenur Deniz SongiD· 1 shared Erika Okuno· 1 shared Gebhard F. X. SchertleriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiophysics

Akihisa TerakitaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Self-regenerating opsin from reef-building coral

Yusuke Sakai, Yasushi Imamoto, Shino Inukai, Yuri Tominaga, Tomohiro Sugihara, Takahiro Yamashita, Kota Katayama, Yukiya Kakeyama, Ririka Oka, Erika Okuno, Makoto Iwasaki, Hideki Kandori, Mitsumasa KOYANAGI, Akihisa Terakita

This paper identifies a coral opsin, AtAntho2c, that can autonomously regenerate its inactive state through thermal isomerization of retinal, enabling repeated light responses without exogenous retinal.

bioRxiv · May 28, 2026 · PreprintBiophysics

Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

Yusuke Sakai, Saumik Sen, Tomohiro Sugihara, Yukiya Kakeyama, Makoto Iwasaki, Gebhard F. X. Schertler, Xavier Deupí, Mitsumasa Koyanagi, Akihisa Terakita

This study identifies a novel chloride counterion mechanism in coral opsins that stabilizes the Schiff base proton, enabling light sensitivity without a traditional counterion residue.

bioRxiv · Dec 12, 2024 · PreprintBiophysics

Optogenetic manipulation of Gq-and Gi/o-coupled receptor signaling in neurons and heart muscle cells

Hanako Hagio, Wataru Koyama, Shiori Hosaka, Aysenur Deniz Song, Janchiv Narantsatsral, Kōji Matsuda, Tomohiro Sugihara, Takashi Shimizu, Mitsumasa Koyanagi, Akihisa Terakita, Masahiko Hibi

The paper develops optogenetic tools using animal G protein-coupled bistable rhodopsins to control Gq and Gi/o signaling in neurons and cardiomyocytes, showing their utility in vivo.

eLife · Jul 31, 2023Peer-reviewedNeuroscience