ERK signaling integrates multiple mechanisms to drive cortical evolutionary expansion
Tongye Fu, Zhuangzhi Zhang, Wenhui Zheng, Chunli Yang, Zizhuo Sha, Danyu Han, Jialin Li, Feihong Yang, Jingzhe Yu, Zhenmeiyu Li, You Yan, Tong Ma, Weiwei Li, Guoping Liu, Xiaolei Song, , Zhengang Yang
The paper shows that enhanced ERK signaling in human cortical radial glia drives cortical neuron expansion through interactions with PKA signaling and cell cycle regulation.
bioRxiv · Jul 28, 2026 · PreprintDevelopmental Biology