Autophagy disruption primes CAR-T cell metabolism for sustained rejection of ovarian tumors
Gillian A. Carleton, Sébastien Levesque, Lauren G. Zacharias, João S. Patrício, Tracey Sutcliffe, Peter Hamilton Watson, Ralph J. DeBerardinis, Yannick Doyon, Julian J. Lum
This study shows that disrupting autophagy in CAR-T cells enhances their metabolic activity and improves their ability to reject ovarian tumors in vivo.
bioRxiv · Oct 9, 2025 · PreprintImmunology