Yannick Doyon

Autophagy disruption primes CAR-T cell metabolism for sustained rejection of ovarian tumors

This study shows that disrupting autophagy in CAR-T cells enhances their metabolic activity and improves their ability to reject ovarian tumors in vivo.

NTBC dosing and outcomes in hereditary tyrosinemia type 1: insights from a representative human model and 99 patients

This study identifies the minimal effective NTBC dose to prevent liver damage in HT1 using an in vitro model and validates it in 99 patients, while highlighting residual gene dysregulation linked to cancer risk.

In vivo dissection of the mouse tyrosine catabolic pathway with CRISPR-Cas9 identifies modifier genes affecting hereditary tyrosinemia type 1

The paper uses CRISPR-Cas9 in mice to identify modifier genes that affect the severity of tyrosinemia type 1 by editing enzymes in the tyrosine catabolic pathway.

Marker-free coselection for successive rounds of prime editing in human cells

This paper introduces a coselection strategy for prime editing in human cells using the Na+/K+ ATPase to enable efficient multiallelic editing and reduce the need for pegRNA optimization.

Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.

Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9

This paper engineers CRISPR-Cas9 variants from Streptococcus thermophilus to target diverse A-rich PAMs, enabling efficient genome editing in mice.

A marker-free co-selection strategy for high efficiency human genome engineering

This paper introduces a marker-free co-selection strategy to enhance gene editing efficiency in human cells using CRISPR-Cas9 and Cpf1 systems.