Stepwise DNA unwinding gates TnpB genome-editing activity
Zehan Zhou, Iren Saffarian-Deemyad, Honglue Shi, Trevor Weiss, Muhammad Moez ur-Rehman, Kamakshi Vohra, Petr Skopintsev, Peter H. Yoon, Marena I. Trinidad, Conner J. Langeberg, Maris Kamalu, Jasmine Amerasekera, Yuxing Zhou, Erin E. Doherty, Kevin Aris, , Jennifer A. Doudna
Ymu1 TnpB unwinds DNA via a long-lived partially unwound intermediate before a rarely stable open state; the WFR triple variant stabilizes both, boosting plant editing.
Molecular Cell · Aug 1, 2026Peer-reviewedBiochemistry✦ In-depth digest