Author

Tristan Melfi

State University of New York

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Alan A. CheniD· 2 shared Jibin Abraham PunnooseiD· 2 shared Ken HalvorseniD· 2 shared Sweta VangavetiiD· 2 shared Arun Richard ChandrasekaraniD· 1 shared Bharath Raj MadhanagopaliD· 1 shared Chai S. Kam· 1 shared Dadrian Cole· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 32 mutual co-author links

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2 shared papersBiophysics

Alan A. ChenORCID

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2 papers

Recent·Most cited

Investigating polarity effects in DNA base stacking

Jibin Abraham Punnoose, Chai S. Kam, Tristan Melfi, Sweta Vangaveti, Alan A. Chen, Ken Halvorsen

This study investigates how DNA strand polarity affects base-stacking energetics using single-molecule and computational methods, finding polarity-dependent stability differences in purine-purine and purine-pyrimidine interactions.

JACS Au · Nov 28, 2025Peer-reviewedBiophysics

Tuning the stability of DNA tetrahedra with base-stacking interactions

Jibin Abraham Punnoose, Dadrian Cole, Tristan Melfi, Vinod Morya, Bharath Raj Madhanagopal, Alan A. Chen, Sweta Vangaveti, Arun Richard Chandrasekaran, Ken Halvorsen

This study investigates how base-stacking interactions affect the stability of DNA tetrahedra by testing 16 designs, finding that altering a single base stack can change melting temperatures by up to 10°C.

Nano Letters · Feb 20, 2025Peer-reviewedBioengineering