Alan A. Chen

This study investigates how DNA strand polarity affects base-stacking energetics using single-molecule and computational methods, finding polarity-dependent stability differences in purine-purine and purine-pyrimidine interactions.

This study investigates how miR-34a interacts with its mRNA targets and how AGO2 modulates their binding affinity and structure, revealing structural determinants of repression efficacy.

This study investigates how base-stacking interactions affect the stability of DNA tetrahedra by testing 16 designs, finding that altering a single base stack can change melting temperatures by up to 10°C.

This study investigates how pseudoknot base pairing affects cotranscriptional structural switching in fluoride riboswitches, showing a critical wobble base pair is essential for function across different temperatures.

The paper uses molecular dynamics simulations to study how RNA modifications and magnesium ions affect tRNAPhe conformational dynamics in S. cerevisiae.