Sweta Vangaveti

Multi-dimensional DNA nanostructures isothermally assembled in hydrated ionic liquids

This paper demonstrates the isothermal assembly of DNA nanostructures and 3D crystals in hydrated ionic liquids, enhancing biostability and enabling cell internalization without thermal annealing.

Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy

Quercetin reduces toxic RNA levels and rescues MBNL-dependent mis-splicing in DM1 and DM2 models.

Investigating polarity effects in DNA base stacking

This study investigates how DNA strand polarity affects base-stacking energetics using single-molecule and computational methods, finding polarity-dependent stability differences in purine-purine and purine-pyrimidine interactions.

Temporal Control of CRISPR-Cas9 Activity Using Bio-orthogonal Chemistry.

This paper introduces a method to temporally control CRISPR-Cas9 activity using bio-orthogonal chemistry, demonstrating its effectiveness in live cells and therapeutic applications.

Influence of metal ions on the isothermal self-assembly of DNA nanostructures

This study shows that metal ions and temperature affect DNA nanostructure self-assembly, with divalent ions enabling assembly at lower temperatures and no adverse effects on cell viability.

Tuning the stability of DNA tetrahedra with base-stacking interactions

This study investigates how base-stacking interactions affect the stability of DNA tetrahedra by testing 16 designs, finding that altering a single base stack can change melting temperatures by up to 10°C.

CAG repeat-selective compounds reduce abundance of expanded CAG RNAs in patient cell and murine models of SCAs

The paper identifies small molecules that reduce expanded CAG RNA abundance in SCA patient and mouse models, showing repeat-selective effects across multiple SCAs.

Elucidating the influence of RNA modifications and Magnesium ions on tRNAPhe conformational dynamics in S. cerevisiae: Insights from Replica Exchange Molecular Dynamics simulations

The paper uses molecular dynamics simulations to study how RNA modifications and magnesium ions affect tRNAPhe conformational dynamics in S. cerevisiae.