Selective knockout of PKA regulatory subunits reveal opposite catalytic and metabolic consequences with implications for Alzheimer's disease
Leigh-Ana M. Rossitto, Tsan Wen Lu, Yuliang Ma, Pallavi Kaila Sharma, Valeria Burghi, Carlos G. Gonzalez, Jessica G. H. Bruystens, Svetlana Rajkumar Maurya, Jian Wu, Alexis Lona, Irina Kufareva, Jorge Silvio Gutkind, David J. Gonzalez, Xu Chen, Susan Serota Taylor
This study shows that knocking out PKA regulatory subunits RI and RII leads to distinct metabolic and phosphorylation changes, with RI KO increasing Tau phosphorylation linked to Alzheimer's disease.
bioRxiv · Jun 29, 2026 · PreprintBiochemistry