Jian Wu

Selective knockout of PKA regulatory subunits reveal opposite catalytic and metabolic consequences with implications for Alzheimer's disease

This study shows that knocking out PKA regulatory subunits RI and RII leads to distinct metabolic and phosphorylation changes, with RI KO increasing Tau phosphorylation linked to Alzheimer's disease.

S-nitrosylation of protein kinase A is required for its activation by GPCRs

This study shows that S-nitrosylation of PKA regulatory subunits by SCAN is required for GPCR-induced PKA activation in heart, brain, and fat tissues.

A Structural Mechanism for Noncanonical GPCRSignal Transduction in the Hedgehog Pathway

The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.

Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop

The paper investigates the role of the C-β4 loop in protein kinase structure and dynamics, showing its importance in hydrophobic spine architecture and communication between kinase lobes.

Neurodegeneration Risk Factor, EIF2AK3 (PERK), Influences Tau Protein Aggregation

This study shows that PERK activity prevents tau aggregation and that reduced PERK signaling increases tau neuropathology in tauopathies.