Xu Chen

This study shows that knocking out PKA regulatory subunits RI and RII leads to distinct metabolic and phosphorylation changes, with RI KO increasing Tau phosphorylation linked to Alzheimer's disease.

This study shows that Catestatin reduces Tau pathology and amyloid plaque formation by inhibiting adrenergic signaling in mouse models of neurodegenerative diseases.

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

The paper shows that PrPC ligands in human neurons trigger PLCγ1 signaling and an Arc/Arg3.1 response, indicating neuronal hyperactivity in prion disease.

This study links phosphoproteome modifications to cortical circuit dysfunction in early-stage alpha-synuclein aggregation using multi-omics analysis in rat and mouse models.