Author

Jessica G. H. Bruystens

University of California San DiegoORCID 0009-0000-8192-814XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Jian WuiD· 2 shared Susan Serota TayloriD· 2 shared Alexis LonaiD· 1 shared Annabel LeeiD· 1 shared Benjamin R. MyersiD· 1 shared Carlos G. GonzaleziD· 1 shared Corvin D. ArvesethiD· 1 shared Daniela BertinettiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Jian WuORCID

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2 papers

Recent·Most cited

Selective knockout of PKA regulatory subunits reveal opposite catalytic and metabolic consequences with implications for Alzheimer's disease

Leigh-Ana M. Rossitto, Tsan Wen Lu, Yuliang Ma, Pallavi Kaila Sharma, Valeria Burghi, Carlos G. Gonzalez, Jessica G. H. Bruystens, Svetlana Rajkumar Maurya, Jian Wu, Alexis Lona, Irina Kufareva, Jorge Silvio Gutkind, David J. Gonzalez, Xu Chen, Susan Serota Taylor

This study shows that knocking out PKA regulatory subunits RI and RII leads to distinct metabolic and phosphorylation changes, with RI KO increasing Tau phosphorylation linked to Alzheimer's disease.

bioRxiv · Jun 29, 2026 · PreprintBiochemistry

A Structural Mechanism for Noncanonical GPCRSignal Transduction in the Hedgehog Pathway

William Paul Steiner, Nathan Iverson, G Liu, Varun Venkatakrishnan, Jian Wu, Tomasz Maciej Stępniewski, Zachary Michaelson, Jan W. Bröckel, Ju‐Fen Zhu, Jessica G. H. Bruystens, Annabel Lee, Isaac B. Nelson, Daniela Bertinetti, Corvin D. Arveseth, Gerald Tan, , Benjamin R. Myers

The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.

Nature Structural & Molecular Biology · Apr 30, 2026Peer-reviewedBiochemistry