Developmental prefrontal myelination shapes inhibitory interneuron function and adult social behavior
Takahira Yamauchi, Kohei Kamikawa, Kazuhiko Yamamuro, Hisayoshi Kubota, Minobu Ikehara, Tsutomu Takeda, Kazuki Okumura, Michihiro Toritsuka, Shouta Sugio, Atsuko Nagaoka, Mizuki Hino, Julio Leon, Satoshi Yoshinaga, Hiroki Ikeda, Kazuki Kurimoto, , Manabu Makinodan
This study shows that disrupting developmental myelination in the medial prefrontal cortex impairs adult social behavior and PV interneuron function in mice, with parallels in human schizophrenia.
bioRxiv · Oct 11, 2026 · PreprintNeuroscience