Julio Leon

Developmental prefrontal myelination shapes inhibitory interneuron function and adult social behavior

This study shows that disrupting developmental myelination in the medial prefrontal cortex impairs adult social behavior and PV interneuron function in mice, with parallels in human schizophrenia.

DAP12-deficient microglia adopt a TREM2-independent antigen-presenting state with a glial-to-neuronal cascade in Nasu-Hakola disease

The paper profiles NHD microglia and shows they adopt an antigen-presenting state without TREM2 dependence, triggering glial-to-neuronal changes.

Spatial transcriptome-metabolome integration reveals region-specific glial lipid dysregulation linked to Alzheimer's pathology

The paper develops a spatial multi-omic method to study lipid dysregulation in Alzheimer's disease across brain regions in mice, identifying region-specific glial metabolic changes.

Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia

The paper identifies altered layer 1 astrocytes in schizophrenia using spatial and single-nucleus transcriptomics of the anterior cingulate cortex.

A single-cell atlas of transcribed cis-regulatory elements in the human genome

The paper constructs a single-cell atlas of transcribed cis-regulatory elements in the human genome, revealing gene regulation patterns and trait-gene relationships across cell populations.