David J. H. Shih

Deciphering the Genomic Landscape of Renal Cell Carcinoma Brain Metastases

The paper identifies recurrent copy-number alterations in RCC brain metastases and shows their association with poor prognosis and metastatic potential across multiple cancers.

Medulloblastoma Forms Symbiotic Metabolic Partnerships with Macrophages to Establish Leptomeningeal Metastases

This study identifies metabolic partnerships between medulloblastoma and macrophages that drive leptomeningeal metastases and suggests targeting the CXCL12-SCARB1-cholesterol axis as a therapeutic strategy.

Single-Cell Atlas of Renal Cell Carcinoma Brain Metastasis Uncovers Mechanisms of Immune Dysfunction and Resistance

This study uses single-nucleus RNA-seq to analyze RCC brain metastases, identifying immune evasion mechanisms and metabolic adaptations that contribute to resistance to therapy.

HSC-independent definitive hematopoietic cells persist into adult life

The paper shows that HSC-independent hematopoietic progenitors persist into adulthood, challenging the HSC-centric model of blood cell development.