Author

Jianzhuo Li

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Nicholas E. NaviniD· 3 shared Alastair Mark ThompsoniD· 2 shared Emi SeiiD· 2 shared Jessica Montalvan· 2 shared Shanshan BaiiD· 2 shared Tod D. CasasentiD· 2 shared Aatish ThennavaniD· 1 shared Adeboye O. OsunkoyaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersGenomics

Nicholas E. NavinORCID

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3 papers

Recent·Most cited

Single-Cell Atlas of Renal Cell Carcinoma Brain Metastasis Uncovers Mechanisms of Immune Dysfunction and Resistance

Mohsin Ali, Zeynep Feyza Akpinar, Jose A. Ovando-Ricardez, Tod D. Casasent, Truong Lam, Jerome Lin, Narmina Khanmammadova, Patrick Kevin Reville, David J. H. Shih, Adeboye O. Osunkoya, Lisa M. Norberg, Tuan M. Tran, Jianzhuo Li, Anh G. Hoang, Şahin Hanalıoğlu, , Elshad Hasanov

This study uses single-nucleus RNA-seq to analyze RCC brain metastases, identifying immune evasion mechanisms and metabolic adaptations that contribute to resistance to therapy.

bioRxiv · May 10, 2026 · PreprintCancer Biology

Single cell genome and epigenome co-profiling reveals hardwiring and plasticity in breast cancer

Kaile Wang, Yun Yan, Heba Elgamal, Jianzhuo Li, Chenling Tang, Shanshan Bai, Zhenna Xiao, Emi Sei, Yiyun Lin, Junke Wang, Jessica Montalvan, Changandeep Nagi, Alastair Mark Thompson, Nicholas E. Navin

The paper introduces wellDA-seq, a method to co-profile genome and epigenome in single cells, revealing genetic hardwiring and epigenetic plasticity in breast cancer.

bioRxiv · Sep 6, 2024 · PreprintGenomics

A spatially resolved single cell genomic atlas of the adult human breast

Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Shan Hu, Tod D. Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, , Nicholas E. Navin

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.

Nature · Jun 28, 2023Peer-reviewedGenomics