Robert S. Welner

This study shows maternal folate levels influence adult hematopoietic stem cell function through mitochondrial and chromatin changes in offspring.

This study identifies somatic DDX41 mutations as gain-of-function alleles that drive aberrant splicing, particularly of SEPTIN7, contributing to MDS/AML pathogenesis.

The paper identifies conserved transcriptional programs in pancreatic cancer liver metastases and shows how they interact with spatial immune microenvironments to drive metastatic progression.

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

This study identifies CDK8 mis-splicing as a driver of altered progenitor fate in SF3B1-mutant MDS, linking splicing defects to transcriptional dysregulation and lineage commitment.

This paper establishes a humanized mouse model of glioblastoma using patient-derived xenografts to study immune infiltration and tumor heterogeneity, finding immune cell profiles similar to recurrent human GBM.

This study shows that Gfi1 regulates the formation of exhausted effector-like CD8 T cells during chronic infection and cancer, impacting their differentiation and function.

GOALS introduces a novel framework for analyzing Gene Ontologies by discretizing them into optimal layers to enhance functional insights and visualization in biological processes.

The paper introduces todenE, a clustering method combining topology and density-based approaches to group PAGs into Super-PAGs, improving functional representation in genomics.

Prenatal inflammation induces hyperactivated ILC2s in the developing lung, leading to increased asthma susceptibility through immune remodeling.

This study develops a mouse model of ZTTK syndrome by creating Son haploinsufficiency mice, revealing critical roles of SON in organ development and hematopoiesis.