Author

Tucker L. Conklin

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Elizabeth W. KahunoiD· 2 shared Haley E. MelikianiD· 2 shared Patrick J. KearneyiD· 2 shared Gert LübeciD· 1 shared Gilles E. MartiniD· 1 shared Nicholas C. BoldeniD· 1 shared Rebecca G. Pavchinskiy· 1 shared Rita R. FaganiD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Elizabeth W. KahunoORCID

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2 papers

Recent·Most cited

Rit2 loss in dopaminergic neurons drives a Parkinsonian phenotype

Patrick J. Kearney, Yuanxi Zhang, Yanglan Tan, Elizabeth W. Kahuno, Tucker L. Conklin, Rita R. Fagan, Rebecca G. Pavchinskiy, Scott A. Shafer, Zhenyu Yue, Haley E. Melikian

This study shows that Rit2 loss in dopamine neurons causes PD-like symptoms in mice, with sex-specific differences in disease progression and response to treatment.

bioRxiv · Apr 26, 2023 · PreprintNeuroscience

Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function

Patrick J. Kearney, Nicholas C. Bolden, Elizabeth W. Kahuno, Tucker L. Conklin, Gilles E. Martin, Gert Lübec, Haley E. Melikian

This study shows that activating presynaptic Gq-coupled receptors causes biphasic DAT trafficking, affecting dopamine clearance and motor function.

Journal of Biological Chemistry · Jan 11, 2023Peer-reviewedNeuroscience