Rit2 loss in dopaminergic neurons drives a Parkinsonian phenotype
Patrick J. Kearney, Yuanxi Zhang, Yanglan Tan, Elizabeth W. Kahuno, Tucker L. Conklin, Rita R. Fagan, Rebecca G. Pavchinskiy, Scott A. Shafer, Zhenyu Yue, Haley E. Melikian
This study shows that Rit2 loss in dopamine neurons causes PD-like symptoms in mice, with sex-specific differences in disease progression and response to treatment.
bioRxiv · Apr 26, 2023 · PreprintNeuroscience