Author

Elizabeth W. Kahuno

University of Massachusetts Chan Medical SchoolORCID 0000-0003-0170-3237Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Haley E. MelikianiD· 2 shared Patrick J. KearneyiD· 2 shared Tucker L. Conklin· 2 shared Allen B. ReitziD· 1 shared Brenda C. ShieldsiD· 1 shared Celine M. CammarataiD· 1 shared Court HulliD· 1 shared Elizabeth A. Fleming· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Haley E. MelikianORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 26, 2023

Rit2 loss in dopaminergic neurons drives a Parkinsonian phenotype

Patrick J. Kearney, Yuanxi Zhang, Yanglan Tan…·Haley E. Melikian

This study shows that Rit2 loss in dopamine neurons causes PD-like symptoms in mice, with sex-specific differences in disease progression and response to treatment.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeuroscienceJournal of Biological ChemistryPeer-reviewedJan 11, 2023

Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function

Patrick J. Kearney, Nicholas C. Bolden, Elizabeth W. Kahuno…·Haley E. Melikian

This study shows that activating presynaptic Gq-coupled receptors causes biphasic DAT trafficking, affecting dopamine clearance and motor function.

16 citations

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 18, 2022

Thousandfold Cell-Specific Pharmacology of Neurotransmission

Brenda C. Shields, Hai Yan, Shaun S.X. Lim…·Michael R. Tadross

The paper introduces DART.2, a method for cell-specific drug delivery, demonstrating robust bidirectional editing of neurotransmission in mice.

5 citations

mouseexperimental assay

𝕏 PostBluesky