An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module
M. Chawla, T. Mukherjee, A. Deka, B. Chatterjee, U. A. Sarkar, A. K. Singh, S. Kedia, B. Banoth, S. K. Biswas, V. Ahuja, S. Basak
The paper shows that noncanonical NF-κB signaling in intestinal epithelial cells enhances latent RelA dimers, amplifying canonical NF-κB activity and exacerbating intestinal inflammation in IBD.
bioRxiv · Nov 2, 2020Immunology