Author

U. Butt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

J. Westermarck· 3 shared D. Connolly· 2 shared J. Pouwels· 2 shared T. Gronroos· 2 shared A. Cvrljevic· 1 shared A. Laine· 1 shared A. N. Cvrljevic· 1 shared A. Ristimaki· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

J. Westermarck

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3 papers

Recent·Most cited

SHARPIN serine 146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion, and metastasis

U. Butt, M. H. Khan, J. Pouwels, J. Westermarck

This study identifies SHARPIN serine 146 phosphorylation as a key regulator of cancer cell invasion and metastasis by mediating ARP2/3 complex interaction and lamellopodia formation.

bioRxiv · Jan 21, 2022Cancer Biology

Ovarian cancers with low CIP2A tumor expression constitute an APR-246 sensitive disease subtype

A. N. Cvrljevic, U. Butt, K. Huhtinen, T. Gronroos, C. Bockelman, H. Lassus, K. Kaipio, A. Ristimaki, T. Arsiola, T. D. Laajala, D. Connolly, O. Carpen, J. Pouwels, J. Westermarck

The paper identifies ovarian cancers with low CIP2A expression as a subtype sensitive to APR-246, a ROS-inducing compound, and shows CIP2A's role in modulating NF-kB activity and drug response.

bioRxiv · Mar 31, 2021Cancer Biology

CIP2A interacts with TopBP1 and is selectively essential for DNA damage-induced basal-like breast cancer tumorigenesis

A. Laine, S. Nagelli, C. Farrington, U. Butt, A. Cvrljevic, J. Vainonen, T. Gronroos, P. Gautam, S. Khan, H. Sihto, X. Qiao, D. Connolly, P. Kronqvist, J. Maurer, K. Wennerberg, , J. Westermarck

This study identifies CIP2A as a subtype-specific driver of DNA damage-induced basal-like breast cancer, showing its role in checkpoint signaling and therapeutic vulnerability.

bioRxiv · Aug 27, 2020Cancer Biology