X. Qiao

Whole-genome resequencing revealed the Origin and Domestication of Chinese Domestic Rabbits

This study uses whole-genome resequencing to trace the origin and domestication of Chinese domestic rabbits, identifying genetic adaptations and multiple potential origins.

Nitrite deteriorates bioreactor performance by reducing growth of Ca. Brocadia sapporoensis instead of inhibiting the anammox activity

This study shows that nitrite reduces the growth of Ca. Brocadia sapporoensis in anammox systems, leading to performance collapse, rather than directly inhibiting anammox activity.

Unravelling Biosynthesis and Biodegradation Potentials of Microbial Dark Matters in Hypersaline Lakes

This study identifies novel biosynthesis and biodegradation potentials in microbial dark matter from hypersaline lakes, expanding genetic resources for biotechnology.

Dalpiciclib Partially Abrogates ER Signaling Activation Induced by Pyrotinib In HER2+HR+ Breast Cancer

The paper investigates how dalpiciclib affects ER signaling activation induced by pyrotinib in HER2+HR+ breast cancer and identifies CALML5 as a risk factor.

Latitude influences stability via stabilizing mechanisms in naturally-assembled forest ecosystems at different spatial grains

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

Conventional dendritic cells 2, the targeted antigen-presenting-cell, induces enhanced type 1 immune responses in mice immunized with CVC1302 in oil formulation

This study shows that CVC1302 in oil formulation enhances Th1 immune responses by targeting antigen and inflammatory monocytes to lymph node inter-follicular regions and promoting IL-12 production by cDC2.

A latitudinal pattern of plant leaf-associated bacterial community assembly

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

Pharmacological PP2A reactivation overcomes multikinase inhibitor tolerance across brain tumor cell models

This study identifies a triplet therapy combining AKT, PDK1-4 inhibition, and PP2A reactivation that effectively eradicates brain tumor models by overcoming kinase inhibitor tolerance through combinatorial effects on signaling rewiring, OXPHOS, and apoptosis.

Dalpiciclib and Pyrotinib Exert Synergistic Antitumor Effects in Triple Positive Breast Cancer

This study shows that combining dalpiciclib with pyrotinib is more effective than pyrotinib with tamoxifen in treating triple-positive breast cancer, with CALML5 as a potential biomarker.

Curvature of the retroviral capsid assembly is modulated by a molecular switch

The paper identifies key residues that enable a molecular switch in retroviral capsid proteins, allowing curvature changes during capsid assembly.

Association of CD44-/CD24- Breast Cancer Cells with Late Stage Tumor Recurrence

This study links CD44-/CD24- breast cancer cells to late-stage tumor recurrence and identifies RHBDL2 as a regulator of CSC conversion.

Robust neutralization assay based on SARS-CoV-2 S-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressed BHK21 cells

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

CIP2A interacts with TopBP1 and is selectively essential for DNA damage-induced basal-like breast cancer tumorigenesis

This study identifies CIP2A as a subtype-specific driver of DNA damage-induced basal-like breast cancer, showing its role in checkpoint signaling and therapeutic vulnerability.

Species packing and the latitudinal gradient in beta-diversity

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

Several FDA-approved drugs effectively inhibit SARS-CoV-2 infection in vitro

This study evaluates 1403 FDA-approved drugs for SARS-CoV-2 inhibition using pseudovirus and authentic virus assays, identifying four compounds with potent effects and a synergistic combination.

Foundation species across a latitudinal gradient in China

The paper identifies candidate foundation species in Chinese forests across a latitudinal gradient and finds they are more common in temperate zones than in tropical or boreal regions.

Control of MYC-dependent apoptotic threshold by a co-amplified ubiquitin E3 ligase UBR5

This study identifies UBR5 as a novel MYC ubiquitin ligase that regulates MYC protein stability and apoptotic threshold in cancer cells and breast tissue.

Impact of fruit-tree shade intensity on the growth, yield, and quality of intercropped wheat

This study examines how different fruit tree shade intensities affect wheat growth, yield, and quality in intercropping systems, finding that shade reduces yield components but increases protein content and dough properties.