NUDT5 regulates the global efficacy of nucleoside analog drugs by coordinating purine synthesis and PRPP allocation
Nicholas C.K. Valerie, Seher Alam, Femke M. Hormann, Ulf Märtens, Bo Lundgren, Massimiliano Gaetani, Johan Boström, Sean G. Rudd, Per I. Arvidsson, Mikael Altun
This study shows NUDT5 regulates the effectiveness of nucleoside analog drugs by coordinating purine synthesis and PRPP allocation through its interaction with PPAT.
bioRxiv · Nov 20, 2025 · PreprintBiochemistry