Author

Sean G. Rudd

Science for Life LaboratoryORCID 0000-0002-4368-3855Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Mikael AltuniD· 2 shared Nicholas C.K. ValerieiD· 2 shared Seher AlamiD· 2 shared André B. P. KuilenburgiD· 1 shared Andrei ChabesiD· 1 shared Bo LundgreniD· 1 shared Femke M. HormanniD· 1 shared Huazhang ShuiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

Mikael AltunORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NUDT5 regulates the global efficacy of nucleoside analog drugs by coordinating purine synthesis and PRPP allocation

Nicholas C.K. Valerie, Seher Alam, Femke M. Hormann, Ulf Märtens, Bo Lundgren, Massimiliano Gaetani, Johan Boström, Sean G. Rudd, Per I. Arvidsson, Mikael Altun

This study shows NUDT5 regulates the effectiveness of nucleoside analog drugs by coordinating purine synthesis and PRPP allocation through its interaction with PPAT.

bioRxiv · Nov 20, 2025 · PreprintBiochemistry

Uridine cytidine kinases dictate the therapeutic response of molnupiravir via its bioactivation

Huazhang Shu, Sushma Sharma, Seher Alam, Lilian Frank, Marianna Tampere, André B. P. Kuilenburg, Nicholas C.K. Valerie, Mikael Altun, Andrei Chabes, Sean G. Rudd, Si Min Zhang

This study identifies uridine cytidine kinases (UCKs) as key enzymes that phosphorylate molnupiravir's active metabolite, influencing its antiviral efficacy and selectivity against SARS-CoV-2.

bioRxiv · May 13, 2025 · PreprintMicrobiology

Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapy

J.S. Wang, Robert Strauss, Jiří Bártek, Sean G. Rudd

This study identifies SLC7A11 as a mediator of cisplatin resistance in cancer cells and shows asparaginase therapy can target this resistance.

bioRxiv · Jul 19, 2024 · PreprintCancer Biology