Johan Boström

The paper introduces a modular lentiviral system for multiplexed gene perturbation and functional analysis, showing that ER+ breast cancer cells rely on AR, ER, and PR for in vivo growth.

The paper integrates single-cell, spatial, and clonal data to study cranial placode development and evolution, revealing continuous transcriptional landscapes and shared progenitors between placodes.

This study shows NUDT5 regulates the effectiveness of nucleoside analog drugs by coordinating purine synthesis and PRPP allocation through its interaction with PPAT.

The paper shows that β-catenin signaling patterns the oral-aboral axis in Nematostella vectensis, but endoderm specification occurs opposite to nuclear β-catenin accumulation, suggesting this mechanism is a Bilateria-specific co-option.