Histones are exosome membrane proteins regulated by cell stress
Birendra Singh, Marcus Fredriksson Sundbom, Uma Muthukrishnan, Balasubramanian Natarajan, Stephanie Stransky, André Görgens, Joel Z. Nordin, Oscar P. B. Wiklander, Linda Sandblad, Simone Sidoli, Samir EL Andaloussi, Michael Haney, Jonathan D. Gilthorpe
This study identifies histones as exosome membrane proteins regulated by cell stress, showing they are secreted via the exosome pathway and lack nuclear post-translational modifications.
Journal of Extracellular Vesicles · Feb 1, 2025Peer-reviewedCell Biology